Open AccessCD137 Promotes Proliferation and Survival of Human B Cells
Author(s) -
Xiaoyu Zhang,
Caroline Voskens,
Michelle A. Sallin,
Amudhan Maniar,
Carolina L. Montes,
Yue Zhang,
Wei Lin,
Guoyan Li,
Erin Burch,
Ming Tan,
Ronna Hertzano,
Andrei I. Chapoval,
Koji Tamada,
Brian Gastman,
Dan H. Schulze,
Scott E. Strome
Publication year - 2009
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.737
H-Index - 372
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.0901619
Subject(s) - cd137 , cd40 , microbiology and biotechnology , in vitro , secretion , cell growth , t cell , biology , chemistry , immunology , cytotoxic t cell , immune system , biochemistry
CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown. We found that CD137 is expressed in vitro on anti-Ig-stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-gamma and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-alpha and -beta. Our study suggests that CD137 costimulation may play a role in defining the fate of Ag-stimulated human B cells.
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