Intranasal Immunization Promotes Th17 Immune Responses | Zendy

Beata M. Zygmunt | Zendy; Faı̈za Rharbaoui | Zendy; Lothar Groebe | Zendy; Carlos A. Guzmán | Zendy

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Intranasal Immunization Promotes Th17 Immune Responses

Author(s) -

Beata M. Zygmunt,

Faı̈za Rharbaoui,

Lothar Groebe,

Carlos A. Guzmán

Publication year - 2009

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.0901144

Subject(s) - immunization , immune system , immunology , c c chemokine receptor type 6 , chemokine , context (archaeology) , tuberculosis vaccines , adjuvant , rar related orphan receptor gamma , chemokine receptor , biology , ccl20 , mycobacterium tuberculosis , nasal administration , medicine , tuberculosis , foxp3 , pathology , paleontology

Th17 cells are a lineage of CD4+ T cells characterized by IL-17 secretion, which plays a crucial role in immune responses against important respiratory pathogens, such as Mycobacterium tuberculosis. In this study, we demonstrated that intranasal (i.n.) immunization leads per se to Th17-biased immune responses, regardless of the adjuvant used. The activated CD4+ T cells also showed an up-regulated expression of the chemokine receptor CCR6, which is a marker for murine Th17 cells. These results have important implications in the context of optimizing rational vaccine design, since i.n. immunization appears to be the strategy of choice for situations where the induction of a Th17 phenotype would be beneficial.

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