Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells | Zendy

Rosalie Molenaar | Zendy; Mascha Greuter | Zendy; Arnold P. J. van der Marel | Zendy; Ramon Roozendaal | Zendy; Stefan F. Martin | Zendy; Fanny Edele | Zendy; Jochen Huehn | Zendy; Reinhold Förster | Zendy; Tom O’Toole | Zendy; Wendy Jansen | Zendy; I.L. Eestermans | Zendy; Georg Kraal | Zendy; Reina E. Mebius | Zendy

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Lymph Node Stromal Cells Support Dendritic Cell-Induced Gut-Homing of T Cells

Author(s) -

Rosalie Molenaar,

Mascha Greuter,

Arnold P. J. van der Marel,

Ramon Roozendaal,

Stefan F. Martin,

Fanny Edele,

Jochen Huehn,

Reinhold Förster,

Tom O’Toole,

Wendy Jansen,

I.L. Eestermans,

Georg Kraal,

Reina E. Mebius

Publication year - 2009

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.0900311

Subject(s) - lymph node stromal cell , homing (biology) , stromal cell , lymphocyte homing receptor , lymph node , microbiology and biotechnology , bone marrow , lymph , dendritic cell , biology , antigen presenting cell , chemistry , t cell , immunology , cell , pathology , cancer research , immune system , medicine , cell adhesion , biochemistry , ecology

T cells are imprinted to express tissue-specific homing receptors upon activation in tissue-draining lymph nodes, resulting in their migration to the site of Ag entry. Expression of gut-homing molecules alpha(4)beta(7) and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by retinal dehydrogenases, which are specifically expressed in dendritic cells as well as stromal cells in mucosa-draining lymph nodes. In this study, we demonstrate that mesenteric lymph node stromal cell-derived retinoic acid can directly induce the expression of gut-homing molecules on proliferating T cells, a process strongly enhanced by bone marrow-derived dendritic cells in vitro. Therefore, cooperation of sessile lymph node stromal cells with mobile dendritic cells warrants the imprinting of tissue specific homing receptors on activated T cells.

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