Coronin 1 Is Essential for IgM-Mediated Ca2+ Mobilization in B Cells but Dispensable for the Generation of Immune Responses In Vivo | Zendy

Benoît Combaluzier | Zendy; Philipp Mueller | Zendy; Jan Massner | Zendy; Daniela Finke | Zendy; Jean Pieters | Zendy

Open Access

Coronin 1 Is Essential for IgM-Mediated Ca2+ Mobilization in B Cells but Dispensable for the Generation of Immune Responses In Vivo

Author(s) -

Benoît Combaluzier,

Philipp Mueller,

Jan Massner,

Daniela Finke,

Jean Pieters

Publication year - 2009

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.0801811

Subject(s) - microbiology and biotechnology , biology , immune system , intracellular , b cell , regulator , breakpoint cluster region , function (biology) , t cell , in vivo , signal transduction , immunology , receptor , antibody , genetics , gene

Coronin 1 is a leukocyte specific regulator of Ca(2+)-dependent signaling and is essential for the survival of peripheral T lymphocytes, but its role in B cells is unknown. In this study, we show that coronin 1 is essential for intracellular Ca(2+) mobilization and proliferation upon triggering of the BCR. However, the presence of costimulatory signals rendered coronin 1 dispensable for B cell signaling, consistent with the generation of normal immune responses against a variety of Ags in coronin 1-deficient mice. We conclude that coronin 1, while being essential for T cell function and survival, is dispensable for B cell function in vivo.

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