Extracellular Vesicles with Exosome-like Features Transfer TLRs between Dendritic Cells | Zendy

Yue Zhang | Zendy; Jingjing Meng | Zendy; Li Zhang | Zendy; Sundaram Ramkrishnan | Zendy; Sabita Roy | Zendy

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Extracellular Vesicles with Exosome-like Features Transfer TLRs between Dendritic Cells

Author(s) -

Yue Zhang,

Jingjing Meng,

Li Zhang,

Sundaram Ramkrishnan,

Sabita Roy

Publication year - 2019

Publication title -

immunohorizons

Language(s) - English

Resource type - Journals

ISSN - 2573-7732

DOI - 10.4049/immunohorizons.1900016

Subject(s) - exosome , microbiology and biotechnology , microvesicles , extracellular vesicle , extracellular vesicles , tlr4 , inflammation , immune system , dendritic cell , extracellular , biology , intracellular , signal transduction , immunology , microrna , gene , biochemistry

Accumulating evidence shows that extracellular vesicles (EVs) secreted by immune cells play an important role in intercellular communication. In the current report, we show that EVs released from wild-type bone marrow-derived dendritic cells (BMDCs) transfer TLRs to TLR4-knockout (TLR4KO) BMDCs and increase cellular responsiveness to LPS in recipient cells. The transferred EVs have exosomal characteristics and induce the activation of NF-κB signaling pathways in recipient cells. We further show that BMDC-derived EVs can promote LPS-induced inflammation in TLR4KO mice in vivo. These results indicate that functional TLR4 can be transferred from wild-type to TLR4KO BMDCs through exosome-like EVs.

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