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Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line
Author(s) -
Hyuck Song,
Tae Young Koo,
Ji Hoon Park,
Ki Hak Song,
Sung Tae Kim,
In Seok Choi,
Won Joon Choi,
Woo Kyun Mok,
Hyun Sik Min,
Dae Sung Yoon
Publication year - 2003
Publication title -
journal of korean breast cancer society
Language(s) - English
Resource type - Journals
ISSN - 1598-3641
DOI - 10.4048/jkbcs.2003.6.4.277
Subject(s) - medicine , genistein , cyclooxygenase , aspirin , breast cancer , cancer , cancer research , enzyme , biology , biochemistry
2001 .(1) cyclooxygenase ( Cox) , Aspirin non-steroidal anti-inflammatory drug (NSAID) Cox . Cox Cox-1 Cox-2 isoenzyme 60% .(2-4) Cox-1 Cox-2 proinflammatory agent . Cox-2 growth factor, inflammatory cytokine, endotoxin , vascular endothelial growth factor (VEGF) . ,(5) ,(6) ,(7) ,(8) (9) Cox-2 , Cox-2 (, , , ) .(10) Cox-2 . Cox-2 selective Cox-2 inhibitor (NS-398) genistein Cox-2 mRNA -(RT-PCR) . isoflavone phytoestrogen (genistein) Cox-2 . :, 685 302-718, Tel: 042-600-9140, Fax: 042-542-0133 E-mail: dsyoonmd@kyuh.co.kr :2003 10 21, :2003 12 18 2003 . Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line

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