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..,,..  1962   nude mouse  T-, nude mouse.   severe combined immunodeficient (SCID) mouse transgenic mouse. SCID mouse 1983 Bosma (1)   ,   16  SCID locus   (allele)DNA  (repair enzyme)   ,   B  T    V-D-J (gene).(2-4)  SCID mousepro-B cell   (immature thymocyte)   ,  B  T    SCID mouse, ,    human cancers including breast cancer. (Journal of Korean Breast Cancer Society 2002;5:273-278)

Growth and Metastasis of MCF-7 Breast Cancer Cells Grafted to huPBMC-SCID Mouse