Basics in molecular evolution of colorectal cancer and their implications for the surgeon: is it a 'big-bang' or a 'survival of the toughest'? | Zendy

Pramodh Chandrasinghe | Zendy

Open Access

Basics in molecular evolution of colorectal cancer and their implications for the surgeon: is it a 'big-bang' or a 'survival of the toughest'?

Author(s) -

Pramodh Chandrasinghe

Publication year - 2018

Publication title -

sri lanka journal of surgery/sri lanka journal of surgery

Language(s) - English

Resource type - Journals

eISSN - 2279-2201

pISSN - 0379-8240

DOI - 10.4038/sljs.v36i2.8511

Subject(s) - medical journal , medicine , sri lanka , ceylon , work (physics) , medical education , public relations , library science , family medicine , political science , sociology , history , ethnology , south asia , mechanical engineering , ancient history , computer science , engineering

Multi disciplinary management of cancer has enabled a comprehensive involvement of clinicians in disease management. For the surgeon involved in colorectal cancer (CRC) management it is pertinent to possess a basic knowledge in tumour biology for effective participation. Several models exist to explain the intra tumour heterogeneity (ITH) seen in cancers; clonal expansion, big-bang theory and the cancer stem cell theory. All of these aim to describe the extreme variability seen within cell populations in solid tumours and their implications on clinical management. This review aims to provide the practising surgeon a basic knowledge of colorectal tumour biology and their implications in clinical phenomena.

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