Caudal regression associated with pre-gestational type 2 diabetes mellitus

Caudal regression syndrome is a spectrum of congenital structural defects associated with uncontrolled pre-gestational diabetes mellitus. Prevalence of this disease is 1 to 2.5 in 100,000 live births and background pre-gestational diabetes increases the risk by 200 fold. We present a case of caudal regression syndrome in a mother having type 2 diabetes mellitus with poor glycaemic control since preconceptional period and early gestation. The condition was diagnosed during anomaly scan at 20 weeks of gestation. Uncontrolled pre-existing diabetes is the most common aetiology for caudal regression syndrome. Therefore, proper preconceptional counseling is essential to optimize blood sugar levels in pre-gestational diabetic women. Carrying out anomaly scans around 20 weeks play a pivotal role in high risk cases in diagnosing foetal anomalies.