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A 61year old male patient with generalized tetanus developed central depression due to combined use of magnesium sulphate, midazolam, morphine and fentanyl. He was successfully treated with magnesium sulphate (MgSO 4 ) infusion with the minimal usage of sedatives and paralytic agents. Lowering of GCS occurred on day 6, 7 and 8 indicating central depression.

Profound central depression during treatment of tetanus with combined magnesium, midazolam, morphine and fentanyl