Screening newborns for congenital hypothyroidism

Correspondence: DLWD, e-mail: . Received 28 February 2008 and revised version accepted 15 December 2008. Competing interests: none declared. FSH receptors was identified in affected family members. Few mutations in FSH receptors have been reported but only one resulting in a gain of function. This mutation broadens the specificity of receptors, so that it responds to another ligand hCG [1,2]. Mutant FSH receptors lead to hypersensitivity to hCG. The onset and evolution of the syndrome coincides with the usual gestational time course fluctuation in hCG levels [3].