Open AccessDetection of Skeletal Lesions by Whole Body Multidetector Computed Tomography in Multiple Myeloma has no Impact on Long-Term Outcomes Post Autologous Hematopoietic Cell Transplantation
Author(s) -
Baldeep Wirk,
Charles H. Bush,
Wei Hou,
Leslie Pettiford,
Jan S. Moreb
Publication year - 2012
Publication title -
world journal of oncology
Language(s) - English
Resource type - Journals
eISSN - 1920-454X
pISSN - 1920-4531
DOI - 10.4021/wjon551w
Subject(s) - medicine , radiology , multiple myeloma , occult , malignancy , lytic cycle , bone marrow , pathology , virus , alternative medicine , virology
Multiple myeloma (MM), a plasma cell malignancy, is the most common cancer to involve the skeleton. Skeletal related events such as pathologic fractures and lytic bone lesions have been associated with poor prognosis. Whole body multidetector computed tomography (WBCT) has been shown to be the most sensitive imaging modality in detecting small osteolytic lesions (< 5 mm) in the spine. The significance of lytic lesions detected only by CT is unknown as is their impact on overall survival of MM. The aim of this study was to evaluate the impact of lytic bone lesions seen only by WBCT on progression free survival (PFS) and overall survival (OS) in MM patients after hematopoietic cell transplantation (HCT).