Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production | Zendy

Aqsa Ahmed | Zendy; Abdullah Saghir Ahmad | Zendy; Renhan Li | Zendy; Waleed ALAnsi | Zendy; Momal Fatima | Zendy; Bilal Sajid Mushtaq | Zendy; Samra Basharat | Zendy; Ye Li | Zendy; Zhonghu Bai | Zendy

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Recent Advances in Synthetic, Industrial and Biological Applications of Violacein and Its Heterologous Production

Author(s) -

Aqsa Ahmed,

Abdullah Saghir Ahmad,

Renhan Li,

Waleed ALAnsi,

Momal Fatima,

Bilal Sajid Mushtaq,

Samra Basharat,

Ye Li,

Zhonghu Bai

Publication year - 2021

Publication title -

journal of microbiology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 64

eISSN - 1738-8872

pISSN - 1017-7825

DOI - 10.4014/jmb.2107.07045

Subject(s) - chromobacterium violaceum , corynebacterium glutamicum , yarrowia , industrial microbiology , synthetic biology , heterologous , biology , metabolic engineering , industrial biotechnology , microbiology and biotechnology , computational biology , biochemistry , biofilm , bacteria , quorum sensing , yeast , fermentation , genetics , enzyme , gene

Violacein, a purple pigment first isolated from a gram-negative coccobacillus Chromobacterium violaceum , has gained extensive research interest in recent years due to its huge potential in the pharmaceutic area and industry. In this review, we summarize the latest research advances concerning this pigment, which include (1) fundamental studies of its biosynthetic pathway, (2) production of violacein by native producers, apart from C. violaceum , (3) metabolic engineering for improved production in heterologous hosts such as Escherichia coli, Citrobacter freundii , Corynebacterium glutamicum , and Yarrowia lipolytica , (4) biological/pharmaceutical and industrial properties, (5) and applications in synthetic biology. Due to the intrinsic properties of violacein and the intermediates during its biosynthesis, the prospective research has huge potential to move this pigment into real clinical and industrial applications.

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