Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation | Zendy

Sung Soo Park | Zendy; Seul Ki Lim | Zendy; Jieun Lee | Zendy; Hyo Kyeong Park | Zendy; MinSung Kwon | Zendy; Misun Yun | Zendy; Namhee Kim | Zendy; Young J. Oh | Zendy; HakJong Choi | Zendy

Open Access

Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation

Author(s) -

Sung Soo Park,

Seul Ki Lim,

Jieun Lee,

Hyo Kyeong Park,

MinSung Kwon,

Misun Yun,

Namhee Kim,

Young J. Oh,

HakJong Choi

Publication year - 2021

Publication title -

journal of microbiology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 64

eISSN - 1738-8872

pISSN - 1017-7825

DOI - 10.4014/jmb.2107.07024

Subject(s) - lactobacillus sakei , lipogenesis , adipose tissue , endocrinology , lipid metabolism , medicine , obesity , inflammation , triglyceride , weight gain , probiotic , biology , diet induced obese , cholesterol , food science , body weight , insulin resistance , lactobacillus , fermentation , genetics , bacteria

Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the antiobesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with L. sakei WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of L. sakei WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, L. sakei WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that L. sakei WIKIM31 can be used as a potential therapeutic probiotic for obesity.

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