Inhibitory Effects of Streptomyces sp. MBTH32 Metabolites on Sortase A and Sortase A-Mediated Cell Clumping of Staphylococcus aureus to Fibrinogen | Zendy

Beomkoo Chung | Zendy; Oh-Seok Kwon | Zendy; Jongheon Shin | Zendy; KiBong Oh | Zendy

Open Access

Inhibitory Effects of Streptomyces sp. MBTH32 Metabolites on Sortase A and Sortase A-Mediated Cell Clumping of Staphylococcus aureus to Fibrinogen

Author(s) -

Beomkoo Chung,

Oh-Seok Kwon,

Jongheon Shin,

KiBong Oh

Publication year - 2019

Publication title -

journal of microbiology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 64

eISSN - 1738-8872

pISSN - 1017-7825

DOI - 10.4014/jmb.1906.06026

Subject(s) - sortase a , staphylococcus aureus , peptidoglycan , microbiology and biotechnology , sortase , virulence , cell wall , bacteria , biology , streptomyces , viability assay , biochemistry , chemistry , cell , gene , genetics

Sortase A (SrtA), a type of transpeptidase responsible for anchoring surface proteins to the peptidoglycan cell wall, is important in the virulence of gram-positive bacteria. Three compounds were isolated from marine-derived Streptomyces sp. MBTH32 using various chromatography techniques. The structures of these compounds were determined based on spectroscopic data and comparisons with previously reported data. Among the metabolites tested, lumichrome showed strong inhibitory activity agains Staphylococcus aureus SrtA without affecting cell viability. The results of cell clumping activity assessment suggest the potential for using this compound to trea S. aureus infection by inhibiting SrtA activity.

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