Anti-Angiogenesis Effects Induced by Octaminomycins A and B against HUVECs | Zendy

JunPil Jang | Zendy; Jang Mi Han | Zendy; Hye Jin Jung | Zendy; Hiroyuki Osada | Zendy; JaeHyuk Jang | Zendy; Jong Seog Ahn | Zendy

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Anti-Angiogenesis Effects Induced by Octaminomycins A and B against HUVECs

Author(s) -

JunPil Jang,

Jang Mi Han,

Hye Jin Jung,

Hiroyuki Osada,

JaeHyuk Jang,

Jong Seog Ahn

Publication year - 2018

Publication title -

journal of microbiology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 64

eISSN - 1738-8872

pISSN - 1017-7825

DOI - 10.4014/jmb.1806.06046

Subject(s) - angiogenesis , chorioallantoic membrane , in vivo , protein kinase b , vascular endothelial growth factor , microbiology and biotechnology , biology , pi3k/akt/mtor pathway , chemistry , receptor , therapeutic angiogenesis , phosphorylation , neovascularization , biochemistry , cancer research , pharmacology , signal transduction , vegf receptors , genetics

In the course of studies to discover natural products with anti-angiogenic properties, two cyclic octapeptides, octaminomycins A ( 1 ) and B ( 2 ), were isolated from the cultures of Streptomyces sp. RK85-270. Octaminomycins suppressed the vascular endothelial growth factor (VEGF)-induced proliferation, adhesion, tube formation, migration, and invasion of HUVECs. Anti-angiogenic activity was futher confirmed in vivo by the chicken chorioallantoic membrane assay. We also identified tha 1 and 2 inhibited the phosphorylation of VEGF receptor 2, AKT, and ERK1/2 and the expression and activities of MMP-2 and MMP-9. These results suggest tha 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to angiogenesis-dependent diseases.

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