A Novel Chemical Compound for Inhibition of SARS Coronavirus Helicase | Zendy

JinMoo Lee | Zendy; Jinbeom Cho | Zendy; HeeChul Ahn | Zendy; Woong Jung | Zendy; YongJoo Jeong | Zendy

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A Novel Chemical Compound for Inhibition of SARS Coronavirus Helicase

Author(s) -

JinMoo Lee,

Jinbeom Cho,

HeeChul Ahn,

Woong Jung,

YongJoo Jeong

Publication year - 2017

Publication title -

journal of microbiology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 64

eISSN - 1738-8872

pISSN - 1017-7825

DOI - 10.4014/jmb.1707.07073

Subject(s) - helicase , coronavirus , covid-19 , virology , severe acute respiratory syndrome coronavirus , biology , chemistry , genetics , medicine , outbreak , infectious disease (medical specialty) , rna , gene , disease , pathology

We have discovered a novel chemical compound, (E)-3-(furan-2-yl)- N -(4-sulfamoylphenyl) acrylamide, that suppresses the enzymatic activities of SARS coronavirus helicase. To determine the inhibitory effect, ATP hydrolysis and double-stranded DNA unwinding assays were performed in the presence of various concentrations of the compound. Through these assays, we obtained IC 50 values of 2.09 ± 0.30 µM (ATP hydrolysis) and 13.2 ± 0.9 µM (DNA unwinding), respectively. Moreover, we found that the compound did not have any significant cytotoxicity when 40 µM of it was used. Our results showed that the compound might be useful to be developed as an inhibitor against SARS coronavirus.

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