Lycorine: A Potential Broad-Spectrum Agent Against Crop Pathogenic Fungi | Zendy

Jin-Wen Shen | Zendy; Yuan Ruan | Zendy; Wei Ren | Zendy; Bing-Ji Ma | Zendy; Xiaolong Wang | Zendy; Chun-Feng Zheng | Zendy

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Lycorine: A Potential Broad-Spectrum Agent Against Crop Pathogenic Fungi

Author(s) -

Jin-Wen Shen,

Yuan Ruan,

Wei Ren,

Bing-Ji Ma,

Xiaolong Wang,

Chun-Feng Zheng

Publication year - 2014

Publication title -

journal of microbiology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 64

eISSN - 1738-8872

pISSN - 1017-7825

DOI - 10.4014/jmb.1310.10063

Subject(s) - lycorine , mycelium , fusarium , biology , antifungal , fungi imperfecti , broad spectrum , fungus , microbiology and biotechnology , secondary metabolism , botany , chemistry , alkaloid , biochemistry , enzyme , biosynthesis , combinatorial chemistry

A screening test showed that lycorine exhibited significant antifungal activity against 24 pathogenic crop fungi at concentrations of 500 μg/ml and 100 μg/ml, respectively. Fusarium graminearum was selected for antifungal mechanism studies by observing its mycelial morphology and investigating the variations in its conductivity. In addition, the substance absorption and metabolism of F. graminearum were explored. The mechanism was revealed as being one by which lycorine destroyed the cellular membrane and further influenced substance absorption and cell metabolism.

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