Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca. | Zendy

Young-Hee  Kim | Zendy; In-Ja  Ryoo | Zendy; Soo-Jin  Choo | Zendy; Guang-Hua  Xu | Zendy; Sangku  Lee | Zendy; Soon-Ja  Seok | Zendy; KiHwan  Bae | Zendy; Ick-Dong  Yoo | Zendy

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Clitocybin D, a novel human neutrophil elastase inhibitor from the culture broth of Clitocybe aurantiaca.

Author(s) -

Young-Hee Kim,

In-Ja Ryoo,

Soo-Jin Choo,

Guang-Hua Xu,

Sangku Lee,

Soon-Ja Seok,

KiHwan Bae,

Ick-Dong Yoo

Publication year - 2009

Publication title -

journal of microbiology and biotechnology

Language(s) - English

DOI - 10.4014/jmb.0903.03033

Clitocybin D, a novel human neutrophil elastase inhibitor, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. The compound was determined to be 4-(4,6-dihydroxy-3-methoxy-3H-isoindol-1-yl)-benzoic acid on the basis of 1D and 2D NMRs and MS spectroscopic analysis. Analysis of the human neutrophil elastase (HNE) inhibitory activity of the isolated compound revealed that it showed significant HNE inhibitory activity with an IC(50) value of 17.8 micronM.

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