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The use of sodium 1-(4-amino-5-mercapto-4 H -[1,2,4] triazol-3-yl) and heptadecane-1-sulfonate (2) as new precursors to synthesize some important biologically active heterocycles has been found to be effective. The reaction of 2 with carbon disulphide in pyridine and acid chlorides yielded the 1,2,4-triazole derivatives 3 , 4a and 4b .The condensation of 2 with appropriate aldehydes gave 5a-c which were cyclized by treating with thioglycollic acid to yield 6a-c . The reactions of 2 with phthalic anhydride and 4-methylbenzene-sulfonylchloride gave 7 and 8 . In addition, the reaction of 2 with chloroacetaldehyde, phenacyl bromide, urea and chloroacetyl chloride yielded 9 , 10 , 11 and 12 . At the same time, refluxing 2 with phenyl isothiocyanate gave 13 and 14 . All these products have antimicrobial activity and they can be used as surface active agents.

Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives