Thinning of the Corpus Callosum and Cerebellar Atrophy is Correlated with Phenotypic Severity in a Family with Spastic Paraplegia Type 11 | Zendy

Sanjeev Rajakulendran | Zendy; Coro Paisán-Ruı́z | Zendy; Henry Houlden | Zendy

Open Access

Thinning of the Corpus Callosum and Cerebellar Atrophy is Correlated with Phenotypic Severity in a Family with Spastic Paraplegia Type 11

Author(s) -

Sanjeev Rajakulendran,

Coro Paisán-Ruı́z,

Henry Houlden

Publication year - 2011

Publication title -

journal of clinical neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.208

H-Index - 45

eISSN - 2005-5013

pISSN - 1738-6586

DOI - 10.3988/jcn.2011.7.2.102

Subject(s) - hereditary spastic paraplegia , corpus callosum , spasticity , spastic , atrophy , paraplegia , medicine , pathology , cerebellar ataxia , ataxia , phenotype , genetics , physical medicine and rehabilitation , biology , spinal cord , psychiatry , gene , cerebral palsy

Mutations in the spatacsin gene are associated with spastic paraplegia type 11 (SPG11), which is the most-common cause of autosomal recessive hereditary spastic paraplegia. Although SPG11 has diverse phenotypes, thinning of the corpus callosum is an important feature.

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