Open AccessA Novel Synthesis of 3,4,5,6-Tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd]indole Derivatives from Serotonin
Author(s) -
Masanori Somei,
Sakiko Teranishi,
Ayako Miyashita,
Minoru Ishikura,
Koji Yamada
Publication year - 2011
Publication title -
heterocycles
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.242
H-Index - 64
eISSN - 1881-0942
pISSN - 0385-5414
DOI - 10.3987/com-11-12345
Subject(s) - chemistry , indole test , stereochemistry , combinatorial chemistry
Utilizing novel Nb-substituted serotonins, 5-and/or 6-substituted 3,4,5,6-tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd]indole derivatives are produced simply by treating serotonins with aldehydes under basic conditions. Synthesis of 2,2a,3,4,5,6-hexahydro-7-hydroxy-1H-azepino[5,4,3-cd]indole-2-one derivatives is also reported. © 2011 The Japan Institute of Heterocyclic Chemistry
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