Beyond depression: Other uses for tricyclic antidepressants | Zendy

Joanne Schneider | Zendy; Mary Patterson | Zendy; Xavier Jiménez | Zendy

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Beyond depression: Other uses for tricyclic antidepressants

Author(s) -

Joanne Schneider,

Mary Patterson,

Xavier Jiménez

Publication year - 2019

Publication title -

cleveland clinic journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.359

H-Index - 63

eISSN - 1939-2869

pISSN - 0891-1150

DOI - 10.3949/ccjm.86a.19005

Subject(s) - tricyclic , medicine , fibromyalgia , depression (economics) , migraine , neuropathic pain , dosing , psychiatry , tricyclic antidepressant , antidepressant , anesthesia , pharmacology , anxiety , economics , macroeconomics

Tricyclic antidepressants (TCAs) were originally designed and marketed for treating depression, but over time they have been applied to a variety of conditions, mostly off-label. TCAs can serve as first-line or augmenting drugs for neuropathic pain, headache, migraine, gastrointestinal syndromes, fibromyalgia, pelvic pain, insomnia, and psychiatric conditions other than depression. This article reviews pharmacology, dosing, and safety considerations for these uses.

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