Open AccessObese Mice Fed a Diet Supplemented with Enzyme-Treated Wheat Bran Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria
Author(s) -
Dorothy A. Kieffer,
Brian D. Piccolo,
Maria L. Marco,
Eun Bae Kim,
Michael L. Goodson,
Michael J. Keenan,
Tamara N. Dunn,
Knud Erik Bach Knudsen,
Sean H. Adams,
Roy J. Martin
Publication year - 2016
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.3945/jn.116.238923
Subject(s) - metabolome , biology , lipid metabolism , firmicutes , gut flora , metabolomics , carbohydrate metabolism , metabolism , bran , microbiome , medicine , endocrinology , biochemistry , food science , metabolite , raw material , ecology , bioinformatics , 16s ribosomal rna , gene
Enzyme-treated wheat bran (ETWB) contains a fermentable dietary fiber previously shown to decrease liver triglycerides (TGs) and modify the gut microbiome in mice. It is not clear which mechanisms explain how ETWB feeding affects hepatic metabolism, but factors (i.e., xenometabolites) associated with specific microbes may be involved.
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