Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency–Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus | Zendy

Phu V. Tran | Zendy; Bruce C. Kennedy | Zendy; Marc T. Pisansky | Zendy; KyoungJae Won | Zendy; Jonathan C. Gewirtz | Zendy; Rebecca A. Simmons | Zendy; Michael Georgieff | Zendy

Open Access

Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency–Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus

Author(s) -

Phu V. Tran,

Bruce C. Kennedy,

Marc T. Pisansky,

KyoungJae Won,

Jonathan C. Gewirtz,

Rebecca A. Simmons,

Michael Georgieff

Publication year - 2016

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.3945/jn.115.227561

Subject(s) - hippocampus , choline , reprogramming , endocrinology , iron deficiency , biology , neuroscience , medicine , biochemistry , cell , anemia

Early-life iron deficiency is a common nutrient deficiency worldwide. Maternal iron deficiency increases the risk of schizophrenia and autism in the offspring. Postnatal iron deficiency in young children results in cognitive and socioemotional abnormalities in adulthood despite iron treatment. The rat model of diet-induced fetal-neonatal iron deficiency recapitulates the observed neurobehavioral deficits.

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