Dietary Methyl Donors Contribute to Whole-Body Protein Turnover and Protein Synthesis in Skeletal Muscle and the Jejunum in Neonatal Piglets | Zendy

Jason L. Robinson | Zendy; Scott Harding | Zendy; Janet A. Brunton | Zendy; Robert F. Bertolo | Zendy

Open Access

Dietary Methyl Donors Contribute to Whole-Body Protein Turnover and Protein Synthesis in Skeletal Muscle and the Jejunum in Neonatal Piglets

Author(s) -

Jason L. Robinson,

Scott Harding,

Janet A. Brunton,

Robert F. Bertolo

Publication year - 2016

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.3945/jn.115.226035

Subject(s) - jejunum , skeletal muscle , muscle protein , protein turnover , endocrinology , medicine , protein biosynthesis , biology , biochemistry , chemistry

The neonatal methionine requirement must consider not only the high demand for rapid tissue protein expansion but also the demands as the precursor for a suite of critical transmethylation reactions. However, methionine metabolism is inherently complex because upon transferring its methyl group during transmethylation, methionine can be reformed by the dietary methyl donors choline (via betaine) and folate.

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