L-Glutamine Enhances Tight Junction Integrity by Activating CaMK Kinase 2–AMP-Activated Protein Kinase Signaling in Intestinal Porcine Epithelial Cells | Zendy

Bin Wang | Zendy; Zhenlong Wu | Zendy; Yun Ji | Zendy; Kaiji Sun | Zendy; Zhaolai Dai | Zendy; Guoyao Wu | Zendy

Open Access

L-Glutamine Enhances Tight Junction Integrity by Activating CaMK Kinase 2–AMP-Activated Protein Kinase Signaling in Intestinal Porcine Epithelial Cells

Author(s) -

Bin Wang,

Zhenlong Wu,

Yun Ji,

Kaiji Sun,

Zhaolai Dai,

Guoyao Wu

Publication year - 2016

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.3945/jn.115.224857

Subject(s) - protein kinase a , amp activated protein kinase , microbiology and biotechnology , glutamine , camk , signal transduction , chemistry , kinase , protein kinase c , enzyme , biology , biochemistry , ampk , amino acid , autophosphorylation

The tight junctions (TJs) are essential for maintenance of the intestinal mucosal barrier integrity. Results of our recent work show that dietary l-glutamine (Gln) supplementation enhances the protein abundance of TJ proteins in the small intestine of piglets. However, the underlying mechanisms remain largely unknown.

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