Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site | Zendy

Sharleen O’Reilly | Zendy; Angela Provitera McGlynn | Zendy; Helene McNulty | Zendy; John Reynolds | Zendy; G. R. Wasson | Zendy; Anne M. Molloy | Zendy; JJ Strain | Zendy; Donald G. Weir | Zendy; Mary Ward | Zendy; George McKerr | Zendy; John M. Scott | Zendy; C. Stephen Downes | Zendy

Open Access

Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site

Author(s) -

Sharleen O’Reilly,

Angela Provitera McGlynn,

Helene McNulty,

John Reynolds,

G. R. Wasson,

Anne M. Molloy,

JJ Strain,

Donald G. Weir,

Mary Ward,

George McKerr,

John M. Scott,

C. Stephen Downes

Publication year - 2016

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.3945/jn.115.222547

Subject(s) - folic acid , medicine , gastroenterology , randomized controlled trial , dna , biology , pathology , genetics

Low folate status is associated with an increased risk of colorectal carcinogenesis. Optimal folate status may be genoprotective by preventing uracil misincorporation into DNA and DNA hypomethylation. Adenomatous polyps have low folate status compared with normal colonic mucosa, and they are surrounded by histologically normal mucosa that also is of low folate status.

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