Open AccessLow-Dose Creatine Supplementation Lowers Plasma Guanidinoacetate, but Not Plasma Homocysteine, in a Double-Blind, Randomized, Placebo-Controlled Trial
Author(s) -
Brandilyn A. Peters,
Megan N. Hall,
Xinhua Liu,
Faruque Parvez,
Abu Baker Siddique,
Hasan Shahriar,
Mohammad Nasir Uddin,
Tariqul Islam,
Vesna Ilievski,
Joseph H. Graziano,
Mary V. Gamble
Publication year - 2015
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.3945/jn.115.216739
Subject(s) - creatine , placebo , medicine , homocysteine , plasma homocysteine , endocrinology , chemistry , blood plasma , alternative medicine , pathology
Creatine synthesis from guanidinoacetate consumes ~50% of s-adenosylmethionine (SAM)-derived methyl groups, accounting for an equivalent proportion of s-adenosylhomocysteine (SAH) and total homocysteine (tHcys) synthesis. Dietary creatine inhibits the synthesis of guanidinoacetate, thereby lowering plasma tHcys in rats.
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