Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans1–3 | Zendy

Christina M. van der Beek | Zendy; Johanne G. Bloemen | Zendy; Maartje A. van den Broek | Zendy; Kaatje Lenaerts | Zendy; Koen Venema | Zendy; Wim A. Buurman | Zendy; Cornelis H.C. Dejong | Zendy

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Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans1–3

Author(s) -

Christina M. van der Beek,

Johanne G. Bloemen,

Maartje A. van den Broek,

Kaatje Lenaerts,

Koen Venema,

Wim A. Buurman,

Cornelis H.C. Dejong

Publication year - 2015

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.3945/jn.115.211193

Subject(s) - butyrate , enema , medicine , placebo , gastroenterology , sodium butyrate , splanchnic , short chain fatty acid , chemistry , fermentation , biochemistry , blood flow , pathology , alternative medicine , gene

Short-chain fatty acids (SCFAs), fermentation products of undigested fibers, are considered beneficial for colonic health. High plasma concentrations are potentially harmful; therefore, information about systemic SCFA clearance is needed before therapeutic use of prebiotics or colonic SCFA administration.

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