PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity , | Zendy

Alison M. Mondul | Zendy; Rosellina Margherita Mancina | Zendy; Andrea Merlo | Zendy; Paola Dongiovanni | Zendy; Raffaela Rametta | Zendy; Tiziana Montalcini | Zendy; Luca Valenti | Zendy; Demetrius Albanes | Zendy; Stefano Romeo | Zendy

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PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity ,

Author(s) -

Alison M. Mondul,

Rosellina Margherita Mancina,

Andrea Merlo,

Paola Dongiovanni,

Raffaela Rametta,

Tiziana Montalcini,

Luca Valenti,

Demetrius Albanes,

Stefano Romeo

Publication year - 2015

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.3945/jn.115.210633

Subject(s) - retinol , medicine , nonalcoholic fatty liver disease , endocrinology , overweight , obesity , vitamin , fatty liver , chemistry , disease

Retinol is a lipid-soluble essential nutrient that is stored as retinyl esters in lipid droplets of hepatic stellate cells. Patatin-like phospholipase domain-containing 3 (PNPLA3), through its retinyl-palmitate lipase activity, releases retinol from lipid droplets in hepatic stellate cells in vitro and ex vivo. We have shown that the genetic variant I148M (rs738409) reduces the PNPLA3 retinyl-palmitate lipase activity.

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