Open AccessCitrulline Does Not Prevent Skeletal Muscle Wasting or Weakness in Limb-Casted Mice
Author(s) -
Daniel J. Ham,
Tahnee L. Kennedy,
Marissa K. Caldow,
Annabel Chee,
Gordon S. Lynch,
René Koopman
Publication year - 2015
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.3945/jn.114.203737
Subject(s) - skeletal muscle , medicine , endocrinology , hindlimb , atrophy , muscle atrophy , nitric oxide synthase , chemistry , citrulline , nitric oxide , biology , arginine , biochemistry , amino acid
Increasing arginine (Arg) availability reduces atrophy in cultured skeletal muscle cells. Supplementation with its metabolic precursor citrulline (Cit) is more effective at improving skeletal muscle Arg concentrations.
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