Open AccessIn HepG2 Cells, Coexisting Carnitine Deficiency Masks Important Indicators of Marginal Biotin Deficiency
Author(s) -
Anna Bogusiewicz,
Gunnar Boysen,
Donald M. Mock
Publication year - 2014
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.3945/jn.114.201343
Subject(s) - acetylcarnitine , carnitine , biotin , biotin deficiency , caco 2 , intracellular , endocrinology , chemistry , biochemistry , medicine , biology , cell
A large number of birth defects are related to nutrient deficiencies; concern that biotin deficiency is teratogenic in humans is reasonable. Surprisingly, studies indicate that increased urinary 3-hydroxyisovalerylcarnitine (3HIAc), a previously validated marker of biotin deficiency, is not a valid biomarker in pregnancy.
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