Open AccessLycopene and Apo-10′-lycopenoic Acid Have Differential Mechanisms of Protection against Hepatic Steatosis in β-Carotene-9′,10′-oxygenase Knockout Male Mice
Author(s) -
Blanche C. Ip,
Liu Chun,
Alice H. Lichtenstein,
Johannes von Lintig,
Xiang-Dong Wang
Publication year - 2014
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.3945/jn.114.200238
Subject(s) - steatosis , medicine , endocrinology , fatty liver , fatty acid synthase , liver x receptor , nonalcoholic fatty liver disease , lycopene , biology , chemistry , biochemistry , lipid metabolism , carotenoid , nuclear receptor , transcription factor , gene , disease
Nonalcoholic fatty liver disease is positively associated with obesity and cardiovascular disease risk. Apo-10'-lycopenoic acid (APO10LA), a potential oxidation product of apo-10'-lycopenal that is generated endogenously by β-carotene-9',10'-oxygenase (BCO2) cleavage of lycopene, inhibited hepatic steatosis in BCO2-expressing mice.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom