Open AccessPrenatal Choline Supplementation Ameliorates the Long-Term Neurobehavioral Effects of Fetal-Neonatal Iron Deficiency in Rats
Author(s) -
Bruce C. Kennedy,
Jiva G. Dimova,
Asha Jyothi M Siddappa,
Phu V. Tran,
Jonathan C. Gewirtz,
Michael Georgieff
Publication year - 2014
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.3945/jn.114.198739
Subject(s) - choline , hippocampal formation , offspring , endocrinology , hippocampus , medicine , in utero , fetus , myelin basic protein , iron deficiency , pregnancy , biology , myelin , central nervous system , anemia , genetics
Gestational iron deficiency in humans and rodents produces long-term deficits in cognitive and socioemotional function and alters expression of plasticity genes in the hippocampus that persist despite iron treatment. Prenatal choline supplementation improves cognitive function in other rodent models of developmental insults.
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