Open AccessHaptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency
Author(s) -
Leah E. Cahill,
Ahmed ElSohemy
Publication year - 2010
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.2010.29306
Subject(s) - ascorbic acid , genotype , haptoglobin , vitamin c , medicine , odds ratio , endocrinology , vitamin , single nucleotide polymorphism , allele , chemistry , biology , biochemistry , food science , gene
Haptoglobin (which is encoded by the Hp gene) is a hemoglobin-binding protein that has antioxidant properties and a common polymorphism that consists of 2 structurally different alleles: Hp1 and Hp2. The capacity of Hp2 to inhibit oxidation and vitamin C depletion is less than that of Hp1, but the influence on vitamin C requirements remains unknown.
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