Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City | Zendy

J. Richard Pilsner | Zendy; Howard Hu | Zendy; Robert O. Wright | Zendy; Katarzyna Kordas | Zendy; Adrienne S. Ettinger | Zendy; Brisa N. Sánchez | Zendy; David E. Cantonwine | Zendy; Alicia Lazarus | Zendy; Alejandra Cantoral | Zendy; Lourdes Schnaas | Zendy; Martha María TéllezRojo | Zendy; Mauricio HernándezÁvila | Zendy

Open Access

Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City

Author(s) -

J. Richard Pilsner,

Howard Hu,

Robert O. Wright,

Katarzyna Kordas,

Adrienne S. Ettinger,

Brisa N. Sánchez,

David E. Cantonwine,

Alicia Lazarus,

Alejandra Cantoral,

Lourdes Schnaas,

Martha María TéllezRojo,

Mauricio HernándezÁvila

Publication year - 2010

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.3945/ajcn.2009.28839

Subject(s) - methylenetetrahydrofolate reductase , genotype , medicine , pregnancy , haplotype , cohort , offspring , allele , genetics , biology , gene

Maternal folate nutritional status and prenatal lead exposure can influence fetal development and subsequent health. The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations.

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