Open AccessSphingolipids in human ileostomy content after meals containing milk sphingomyelin
Author(s) -
Lena Ohlsson,
Erik Hertervig,
Bo Jönsson,
RuiDong Duan,
Leyberg,
Rikard Svernlöv,
Åke Nilsson
Publication year - 2010
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.2009.28311
Subject(s) - sphingomyelin , ceramide , sphingosine , sphingolipid , lipase , biochemistry , sphingomyelin phosphodiesterase , cholesterol , chemistry , enzyme , apoptosis , receptor
Sphingomyelin occurs in modest amounts in the diet, in sloughed mucosal cells, and in bile. It is digested by the mucosal enzymes alkaline sphingomyelinase and ceramidase. In humans, alkaline sphingomyelinase is also secreted in bile. The digestion of sphingomyelin is slow and incomplete, which has been linked to the inhibition of cholesterol absorption and colonic carcinogenesis.
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