Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction | Zendy

Luigi Bouchard | Zendy; Rémi RabasaLhoret | Zendy; May Faraj | Zendy; Marie-Ève Lavoie | Zendy; Jonathan Mill | Zendy; Louis Pérusse | Zendy; MarieClaude Vohl | Zendy

Open Access

Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction

Author(s) -

Luigi Bouchard,

Rémi RabasaLhoret,

May Faraj,

Marie-Ève Lavoie,

Jonathan Mill,

Louis Pérusse,

MarieClaude Vohl

Publication year - 2009

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.3945/ajcn.2009.28085

Subject(s) - dna methylation , epigenomics , epigenetics , dieting , biology , endocrinology , medicine , adipose tissue , genetics , weight loss , gene expression , obesity , gene

Caloric restriction is recommended for the treatment of obesity, but it is generally characterized by large interindividual variability in responses. The factors affecting the magnitude of weight loss remain poorly understood. Epigenetic factors (ie, heritable but reversible changes to genomic function that regulate gene expression independently of DNA sequence) may explain some of the interindividual variability seen in weight-loss responses.

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