Open AccessRapid cellular enrichment of eicosapentaenoate after a single intravenous injection of a novel medium-chain triacylglycerol:fish-oil emulsion in humans
Author(s) -
Yvon Carpentier,
Mirjam Hacquebard,
Laurence Portois,
Isabelle Dupont,
Richard J. Deckelbaum,
Willy Malaisse
Publication year - 2010
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.2009.27951
Subject(s) - fish oil , polyunsaturated fatty acid , eicosapentaenoic acid , bolus (digestion) , chemistry , linseed oil , soybean oil , emulsion , fatty acid , docosahexaenoic acid , biochemistry , medicine , food science , biology , fish <actinopterygii> , fishery
Dietary deficiency in n-3 (omega-3) polyunsaturated fatty acids (PUFAs) prevails in Western populations and potentially results in adverse health outcomes. To circumvent the slow n-3 PUFA incorporation in phospholipids of key cells after oral supplementation, a new preparation for intravenous bolus injection was developed with 20 g triacylglycerols/100 mL of a mixture of 80% medium-chain triacylglycerols (MCTs) and 20% fish oil (FO) (wt:wt), and 0.4 g alpha-tocopherol/100 mL of the same mixture.
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