Open AccessPoor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with type 1 diabetes
Author(s) -
Michal Odermarsky,
Jens Lykkesfeldt,
Petru Liuba
Publication year - 2009
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.2009.27602
Subject(s) - medicine , qt interval , intima media thickness , glycated hemoglobin , cardiology , diabetes mellitus , endocrinology , body mass index , repolarization , type 2 diabetes , carotid arteries , electrophysiology
Vascular endothelial dysfunction, accelerated thickening of arterial intima, and changes in ventricular repolarization contribute to increased cardiovascular morbidity in type 1 diabetes (T1D). Although vitamin C has important antioxidant functions and increased oxidative stress is a central mechanism of cardiovascular dysfunction in T1D, the relation between vitamin C and the cardiovascular system in young diabetic patients has not been investigated.
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