Folate is absorbed across the colon of adults: evidence from cecal infusion of 13C-labeled [6S]-5-formyltetrahydrofolic acid | Zendy

Susanne Aufreiter | Zendy; Jesse F. Gregory | Zendy; Christine M Pfeiffer | Zendy; Zia Fazili | Zendy; YoungIn Kim | Zendy; Norman E. Marcon | Zendy; Patarapong Kamalaporn | Zendy; Paul B. Pencharz | Zendy; Deborah L. O’Connor | Zendy

Open Access

Folate is absorbed across the colon of adults: evidence from cecal infusion of 13C-labeled [6S]-5-formyltetrahydrofolic acid

Author(s) -

Susanne Aufreiter,

Jesse F. Gregory,

Christine M Pfeiffer,

Zia Fazili,

YoungIn Kim,

Norman E. Marcon,

Patarapong Kamalaporn,

Paul B. Pencharz,

Deborah L. O’Connor

Publication year - 2009

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.3945/ajcn.2008.27345

Subject(s) - cecum , bioavailability , adverse effect , medicine , physiology , colonoscopy , folic acid , bolus (digestion) , pharmacology , gastroenterology , chemistry , colorectal cancer , cancer

Folate deficiency increases the risk of several human diseases. Likewise, high intakes of folate, particularly synthetic folic acid intake, may be associated with adverse health outcomes in humans. A more comprehensive understanding of the "input side" of folate nutrition may help to set dietary recommendations that strike the right balance between health benefits and risks. It is well known that the microflora in the colon produce large quantities of folate that approach or exceed recommended dietary intakes; however, there is no direct evidence of the bioavailability of this pool in humans.

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