Open AccessDoes the MTHFR 677C→T variant affect the Recommended Dietary Allowance for folate in the US population?
Author(s) -
Julie Robitaille,
Heather C. Hamner,
Mary E. Cogswell,
Quanhe Yang
Publication year - 2009
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.2008.27282
Subject(s) - methylenetetrahydrofolate reductase , medicine , dietary reference intake , population , genotype , ethnic group , gerontology , demography , genetics , biology , environmental health , nutrient , ecology , sociology , gene , anthropology
The MTHFR 677C-->T variant is associated with reduced enzyme activity, abnormalities of folate metabolism, and potential increase in folate requirement. The effect of this variant on the Recommended Dietary Allowance (RDA) for folate is unclear.
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