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Enzymatically hydrolyzed lactotripeptides do not lower blood pressure in mildly hypertensive subjects
Author(s) -
Kim van der Zander,
Michiel L. Bots,
Annette Bak,
M.M.G. Koning,
Peter W. de Leeuw
Publication year - 2008
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.2008.26003
Subject(s) - blood pressure , placebo , medicine , urinalysis , hematocrit , creatinine , excretion , urine , endocrinology , pathology , alternative medicine
Several placebo-controlled clinical studies suggest that products containing isoleucyl-prolyl-proline and valyl-prolyl-proline are able to lower blood pressure without adverse effects. The most efficient way of producing high concentrations of these lactotripeptides (LTPs) is enzymatic hydrolysis of dairy protein (casein) with the use of a mixture of several enzymes derived from the nongenetically modified organism Aspergillus oryzae, including proteases and peptidases. To date, no large studies of the blood pressure-lowering properties of enzymatically produced LTP (ELTP) powder in European populations have been published.

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