Open AccessThe 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans
Author(s) -
Mette Johannsen Mandøe,
Katrine Bagge Hansen,
Bolette Hartmann,
Jens F. Rehfeld,
Jens J. Holst,
Harald S. Hansen
Publication year - 2015
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.115.106799
Subject(s) - chemistry , monoacylglycerol lipase , tributyrin , incretin , cholecystokinin , lipolysis , food science , fatty acid , digestion (alchemy) , fish oil , oleic acid , endocrinology , medicine , biochemistry , adipose tissue , biology , receptor , type 2 diabetes , lipase , chromatography , endocannabinoid system , diabetes mellitus , fishery , fish <actinopterygii> , enzyme
Dietary triglycerides can, after digestion, stimulate the intestinal release of incretin hormones through activation of G protein-coupled receptor (GPR) 119 by 2-monoacylglycerol and by the activation of fatty acid receptors for long- and short-chain fatty acids. Medium-chain fatty acids do not stimulate the release of intestinal hormones.
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