Open AccessAlcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region
Author(s) -
Reiko Nishihara,
Μolin Wang,
Zhi Rong Qian,
Yoshifumi Baba,
Mai Yamauchi,
Kosuke Mima,
Yasutaka Sukawa,
Sun A. Kim,
Kentaro Inamura,
Xuehong Zhang,
Kana Wu,
Edward L. Giovannucci,
Andrew T. Chan,
Charles S. Fuchs,
Shuji Ogino,
Eva Schernhammer
Publication year - 2014
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.114.095539
Subject(s) - colorectal cancer , medicine , methylation , dna methylation , prospective cohort study , proportional hazards model , european prospective investigation into cancer and nutrition , oncology , cancer , risk factor , quartile , endocrinology , physiology , biology , genetics , confidence interval , gene , gene expression
Although a higher consumption of alcohol, which is a methyl-group antagonist, was previously associated with colorectal cancer risk, mechanisms remain poorly understood.
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