Folic acid handling by the human gut: implications for food fortification and supplementation | Zendy

Imran Patanwala | Zendy; Maria J. King | Zendy; David A. Barrett | Zendy; John Rose | Zendy; Ralph Jackson | Zendy; Mark P. Hudson | Zendy; Mark Philo | Zendy; J. Dainty | Zendy; A. Wright | Zendy; Paul Finglas | Zendy; David Jones | Zendy

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Folic acid handling by the human gut: implications for food fortification and supplementation

Author(s) -

Imran Patanwala,

Maria J. King,

David A. Barrett,

John Rose,

Ralph Jackson,

Mark P. Hudson,

Mark Philo,

J. Dainty,

A. Wright,

Paul Finglas,

David Jones

Publication year - 2014

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.3945/ajcn.113.080507

Subject(s) - fortification , food fortification , folic acid , food science , folic acid supplementation , medicine , biology

Current thinking, which is based mainly on rodent studies, is that physiologic doses of folic acid (pterylmonoglutamic acid), such as dietary vitamin folates, are biotransformed in the intestinal mucosa and transferred to the portal vein as the natural circulating plasma folate, 5-methyltetrahydrofolic acid (5-MTHF) before entering the liver and the wider systemic blood supply.

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