Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease | Zendy

Mandana Amir Shaghaghi | Zendy; Çharles N. Bernstein | Zendy; Alejandra Serrano León | Zendy; Hani ElGabalawy | Zendy; Peter Eck | Zendy

Open Access

Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease

Author(s) -

Mandana Amir Shaghaghi,

Çharles N. Bernstein,

Alejandra Serrano León,

Hani ElGabalawy,

Peter Eck

Publication year - 2013

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.3945/ajcn.113.068015

Subject(s) - ascorbic acid , ulcerative colitis , haplotype , allele , single nucleotide polymorphism , genotype , inflammatory bowel disease , crohn's disease , biology , immunology , medicine , genetics , disease , gene , food science

Crohn disease (CD) and ulcerative colitis (UC) are 2 common inflammatory bowel diseases (IBDs) associated with intestinal inflammation and tissue damage. Oxidative stress is suggested to play a major role in the initiation and progression of IBD. Vitamin C (ascorbate, ascorbic acid) supplementation has reduced oxidative stress in persons with IBD. The role of ascorbate transporters in IBD remains to be determined. SLC23A1 is a major ascorbate transporter in the intestinal tract, and some of its genetic variants have been associated with severely decreased ascorbate transport and lower systemic concentrations.

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