Open AccessThe association between MTHFR 677C>T genotype and folate status and genomic and gene-specific DNA methylation in the colon of individuals without colorectal neoplasia
Author(s) -
Joanna Hanks,
Iyeman Ayed,
Neil Kukreja,
Chris Rogers,
Jessica Harris,
Alina Gheorghiu,
Chee Ling Liu,
Peter W. Emery,
Maria Pufulete
Publication year - 2013
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.113.061432
Subject(s) - methylenetetrahydrofolate reductase , dna methylation , genotype , colorectal cancer , methylation , genetics , genomic dna , medicine , gene , biology , cancer , gene expression
Decreased genomic and increased gene-specific DNA methylation predispose to colorectal cancer. Dietary folate intake and the methylenetetrahydrofolate reductase polymorphism (MTHFR 677C>T) may influence risk by modifying DNA methylation.
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