Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester | Zendy

Allyson A. West | Zendy; Jian Yan | Zendy; Xinyin Jiang | Zendy; Cydne A. Perry | Zendy; Sheila M. Innis | Zendy; Marie A. Caudill | Zendy

Open Access

Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester

Author(s) -

Allyson A. West,

Jian Yan,

Xinyin Jiang,

Cydne A. Perry,

Sheila M. Innis,

Marie A. Caudill

Publication year - 2013

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.3945/ajcn.112.050211

Subject(s) - choline , medicine , endocrinology , phosphatidylcholine , docosahexaenoic acid , pregnancy , nefa , phosphatidylethanolamine , fatty acid , polyunsaturated fatty acid , chemistry , biology , phospholipid , biochemistry , membrane , genetics , insulin

Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is enriched with docosahexaenoic acid (DHA). DHA plays a critical role in fetal development and is linked to health endpoints in adulthood. It is unknown whether choline, which can serve as a source of S-adenosylmethionine methyl groups, influences PC-DHA or the PC:PE ratio in pregnant and nonpregnant women.

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